Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Across TCGA cell cohorts, RNA activity of the Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPF3B, PIF1, and HDAC8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UPF3B grouped by Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UPF3B →	+0.746	+1.070	.002	<.001	3	4
SOFT_TISSUE	PIF1 →	+0.978	+1.122	.004	.006	3	4
LARGE_INTESTINE	HDAC8 →	+0.477	+1.015	.006	.007	3	4
OESOPHAGUS	NDUFS8 →	+0.976	+1.259	.004	.006	3	4
OVARY	NKAP →	+0.456	+0.793	.001	.006	3	3
OVARY	NDFIP2 →	-0.986	-1.106	.001	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UPF3B by Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization activity — OVARY

Explore this box plot interactively →