Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Across TCGA cell cohorts, RNA activity of the Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD79A, NCR2, and STK10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD79A grouped by Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CD79A →	+0.236	+0.276	.003	.003	3	6
BLOOD_Myeloma	NCR2 →	-0.344	-0.132	.003	.005	2	6
BLOOD_Leukemia	STK10 →	-0.181	-0.087	.003	.008	3	5
CNS	SH3BP1 →	-0.213	-0.114	<.001	<.001	3	5
LUNG_NSCLC_LUSC	DLAT →	-0.229	-0.194	.002	.003	3	5
UPPER_AERODIGESTIVE_TRACT	CDH12 →	-0.236	-0.208	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD79A by Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →