Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

Across TCGA cell cohorts, RNA activity of the Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAP29, ISL2, and ABCA13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization activity versus BCAP29 in PANCREAS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BCAP29 →	+1.015	+1.520	.007	.002	3	3
BREAST	ISL2 →	+1.315	+0.250	<.001	.001	3	3
LIVER	ABCA13 →	+2.090	+2.031	.003	<.001	3	3
BREAST	EFNA1 →	-1.982	-0.296	<.001	.003	3	3
LUNG_SCLC	SMIM29 →	+0.699	+0.644	.001	.008	3	3
LUNG_SCLC	EIF2AK2 →	+0.625	+0.776	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061734 vs BCAP29 — PANCREAS

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