Lipophagy

Across TCGA cell cohorts, RNA activity of the Lipophagy pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHFR2, PLXNA1, and ZNF396, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipophagy activity versus DHFR2 in KIDNEY (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DHFR2 →	+0.792	+0.105	<.001	<.001	3	5
KIDNEY	PLXNA1 →	+1.438	+0.112	.004	.004	3	5
BLOOD_Myeloma	ZNF396 →	+0.903	+0.109	.003	.008	3	4
BLOOD_Leukemia	SPPL3 →	+0.617	+0.082	.002	.004	3	4
KIDNEY	B4GALT5 →	+1.375	+0.107	.004	.007	3	4
LUNG_SCLC	DUSP5 →	-1.249	-0.073	.006	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061724 vs DHFR2 — KIDNEY

Explore this scatter interactively →