Reticulophagy

Across TCGA patient cohorts, RNA activity of the Reticulophagy pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, DDX21_S89, and EIF3H_S183, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reticulophagy activity versus RPL5 in BRCA (Pearson r = -0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.263	-0.059	<.001	<.001	3	7
BRCA	DDX21_S89 →	-0.881	-0.047	<.001	<.001	3	7
BRCA	EIF3H_S183 →	-0.524	-0.044	<.001	<.001	3	7
BRCA	RPL6 →	-0.447	-0.045	<.001	.001	3	6
GBM	SEPTIN4_S432 →	+0.644	+0.052	<.001	<.001	3	6
BRCA	RPL27A →	-0.349	-0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061709 vs RPL5 — BRCA

Explore this scatter interactively →