Reticulophagy

Across TCGA patient cohorts, RNA activity of the Reticulophagy pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STBD1, H19, and COA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reticulophagy activity versus STBD1 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STBD1 →	+0.367	+0.643	<.001	.003	3	5
BRCA	H19 →	-1.040	-0.543	.001	<.001	3	4
GBM	COA1 →	-0.302	-0.714	.002	<.001	3	4
GBM	SETDB2 →	-0.301	-0.463	<.001	.001	3	4
LSCC	LINC02373 →	-0.280	-0.298	.002	.003	3	3
PDAC	ATRN →	-0.218	-0.525	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061709 vs STBD1 — GBM

Explore this scatter interactively →