Reticulophagy

Across TCGA cell cohorts, RNA activity of the Reticulophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARF1, MRPS2, and TUT7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reticulophagy activity versus ARF1 in BLOOD_Myeloma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ARF1 →	+1.508	+0.266	<.001	.008	3	5
BONE	MRPS2 →	-0.924	-0.173	.004	.002	2	6
BLOOD_Lymphoma	TUT7 →	+0.779	+0.319	<.001	<.001	3	4
LUNG_SCLC	ZDHHC5 →	+0.605	+0.228	<.001	<.001	3	4
LUNG_SCLC	EHBP1L1 →	+1.566	+0.196	.002	.006	3	4
BLOOD_Lymphoma	EXOC8 →	+0.858	+0.235	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061709 vs ARF1 — BLOOD_Myeloma

Explore this scatter interactively →