Detoxification of inorganic compound

Across TCGA patient cohorts, RNA activity of the Detoxification of inorganic compound pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT2A, MT1E, and MT1G, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of inorganic compound activity versus MT2A in LIHC (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MT2A →	+2.589	+0.124	<.001	<.001	3	32
LIHC	MT1E →	+3.768	+0.133	<.001	<.001	3	32
THCA	MT1G →	+5.050	+0.103	<.001	<.001	3	31
THCA	MT1F →	+2.985	+0.103	<.001	<.001	3	31
LIHC	MT1X →	+3.139	+0.130	<.001	<.001	3	30
TGCT	MT1M →	+3.400	+0.128	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061687 vs MT2A — LIHC

Explore this scatter interactively →