Detoxification of inorganic compound

Across TCGA patient cohorts, RNA activity of the Detoxification of inorganic compound pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BUB3, RBM12, and SUPT6H, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of inorganic compound activity versus BUB3 in PDAC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BUB3 →	-0.266	-0.112	<.001	<.001	3	9
COAD	RBM12 →	-0.223	-0.092	<.001	<.001	3	9
GBM	SUPT6H →	-0.324	-0.133	<.001	<.001	3	8
BRCA	VEZF1 →	-0.530	-0.070	<.001	<.001	3	8
GBM	ZFR →	-0.237	-0.102	<.001	<.001	3	8
LSCC	PNN →	-0.333	-0.098	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061687 vs BUB3 — PDAC

Explore this scatter interactively →