Detoxification of inorganic compound

Across TCGA cell cohorts, RNA activity of the Detoxification of inorganic compound pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC63, KDM6B, and GBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC63 grouped by Detoxification of inorganic compound-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SEC63 →	+0.823	+1.236	.002	<.001	3	4
LUNG_NSCLC_LUSC	KDM6B →	+1.181	+1.844	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GBP3 →	-2.007	-1.015	.002	.008	3	4
UPPER_AERODIGESTIVE_TRACT	NFE2L3 →	-1.512	-1.054	.006	.006	3	4
OVARY	PRR36 →	+1.380	+1.265	<.001	<.001	3	4
BLOOD_Lymphoma	C19orf38 →	+1.510	+1.737	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC63 by Detoxification of inorganic compound activity — BLOOD_Myeloma

Explore this box plot interactively →