Detoxification of inorganic compound

Across TCGA cell cohorts, RNA activity of the Detoxification of inorganic compound pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDOC, PTMA, and PCNP, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of inorganic compound activity versus ALDOC in LARGE_INTESTINE (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDOC →	+1.883	+0.294	<.001	<.001	3	14
URINARY_TRACT	PTMA →	+3.098	+0.514	.006	<.001	3	13
LARGE_INTESTINE	PCNP →	+1.513	+0.204	<.001	.001	3	13
URINARY_TRACT	ABCB6 →	+2.843	+0.323	<.001	.004	3	13
UPPER_AERODIGESTIVE_TRACT	HMGB2 →	+2.268	+0.343	<.001	<.001	3	13
LUNG_NSCLC_LUSC	BTF3L4 →	+1.741	+0.197	.004	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061687 vs ALDOC — LARGE_INTESTINE

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