Mitochondrial ribosome assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial ribosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ESYT1_S1064, INPP5A, and ARFGAP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial ribosome assembly activity versus ESYT1_S1064 in UCEC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ESYT1_S1064 →	-0.851	-0.134	.007	.001	3	4
GBM	INPP5A →	+0.503	+0.045	.001	<.001	3	4
OV	ARFGAP3 →	-0.355	-0.044	.002	.005	3	4
PDAC	RASAL3_S831 →	+0.282	+0.033	.004	.001	3	4
OV	RHBDF2_S385 →	-0.806	-0.055	.002	.007	3	3
OV	RPRD2_S909 →	+0.698	+0.059	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061668 vs ESYT1_S1064 — UCEC

Explore this scatter interactively →