Mitochondrial ribosome assembly

Across TCGA cell cohorts, RNA activity of the Mitochondrial ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPN2, TCEANC, and MOCOS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPN2 grouped by Mitochondrial ribosome assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GPN2 →	-0.918	-0.287	.002	.002	2	4
LARGE_INTESTINE	TCEANC →	-0.458	-1.008	.007	.001	3	3
LARGE_INTESTINE	MOCOS →	-1.359	-1.188	.004	<.001	3	3
LARGE_INTESTINE	GSK3B →	-0.808	-1.223	<.001	<.001	3	3
SOFT_TISSUE	KMT5B →	-0.447	-0.651	.001	.008	3	3
BLOOD_Myeloma	MLYCD →	-0.860	-0.533	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPN2 by Mitochondrial ribosome assembly activity — KIDNEY

Explore this box plot interactively →