Mitochondrial ribosome assembly

Across TCGA cell cohorts, RNA activity of the Mitochondrial ribosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NHP2, CHCHD4, and TMBIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial ribosome assembly activity versus NHP2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NHP2 →	+0.811	+0.987	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CHCHD4 →	+1.045	+1.308	.002	<.001	3	5
SKIN	TMBIM1 →	-0.699	-0.861	.008	.006	3	5
OESOPHAGUS	ITM2C →	-1.270	-1.220	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TCOF1 →	+0.790	+1.201	.007	.002	3	4
LUNG_SCLC	HSPA9 →	+0.811	+0.968	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061668 vs NHP2 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →