Protein localization to CENP-A containing chromatin

Across TCGA patient cohorts, RNA activity of the Protein localization to CENP-A containing chromatin pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTK_S436, DNMT3A_S105, and RFC1_T506, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to CENP-A containing chromatin activity versus TTK_S436 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TTK_S436 →	+0.648	+0.059	.006	.002	3	6
OV	DNMT3A_S105 →	+1.210	+0.076	<.001	<.001	3	5
LUAD	RFC1_T506 →	+0.880	+0.068	<.001	<.001	3	5
GBM	ATAD2_S1139 →	+1.161	+0.085	<.001	.009	2	6
GBM	SMARCA4_S1452 →	+0.367	+0.089	<.001	<.001	3	5
GBM	SMARCA4_S1484 →	+0.367	+0.089	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061644 vs TTK_S436 — LSCC

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