Protein localization to CENP-A containing chromatin

Across TCGA patient cohorts, RNA activity of the Protein localization to CENP-A containing chromatin pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCLRE1C, MIR1205, and SLC39A14, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to CENP-A containing chromatin activity versus DCLRE1C in COAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DCLRE1C →	-0.305	-0.733	.007	.004	3	2
COAD	MIR1205 →	+0.779	+0.995	.003	<.001	3	2
GBM	SLC39A14 →	+1.317	+0.262	.001	<.001	3	1
GBM	CAV1 →	+2.046	+0.320	.002	.002	3	1
GBM	PITX3 →	+0.251	+0.225	.008	.001	3	1
GBM	CYTH1 →	-0.831	-0.214	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061644 vs DCLRE1C — COAD

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