Protein localization to CENP-A containing chromatin

Across TCGA cell cohorts, RNA activity of the Protein localization to CENP-A containing chromatin pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM132A, IL16, and MYL12A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM132A grouped by Protein localization to CENP-A containing chromatin-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM132A →	+1.295	+1.436	.001	<.001	3	5
CNS	IL16 →	-0.610	-1.321	.008	<.001	3	4
BLOOD_Myeloma	MYL12A →	-0.899	-2.136	.004	<.001	3	4
BLOOD_Myeloma	EXOSC2 →	+1.297	+1.748	.003	.004	3	4
BREAST	EGLN1 →	-0.657	-0.753	.009	.006	3	4
LUNG_NSCLC_LUAD	NUDT14 →	+0.734	+0.843	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM132A by Protein localization to CENP-A containing chromatin activity — OESOPHAGUS

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