Chemorepulsion of axon

Across TCGA patient cohorts, RNA activity of the Chemorepulsion of axon pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HILPDA, GYS1, and PPP1R13L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chemorepulsion of axon activity versus HILPDA in PDAC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HILPDA →	+1.422	+0.361	<.001	<.001	3	4
PDAC	GYS1 →	+0.576	+0.266	.001	<.001	3	3
BRCA	PPP1R13L →	+0.686	+0.277	.001	.005	3	3
BRCA	UCN2 →	+0.633	+0.280	<.001	.007	3	3
PDAC	LINC01705 →	+1.524	+0.266	.002	<.001	3	3
PDAC	CLEC5A →	+1.209	+0.223	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061643 vs HILPDA — PDAC

Explore this scatter interactively →