Chemorepulsion of axon

Across TCGA cell cohorts, RNA activity of the Chemorepulsion of axon pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A23, MEAF6, and CYP19A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A23 grouped by Chemorepulsion of axon-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC25A23 →	+0.936	+0.714	<.001	.001	3	3
PANCREAS	MEAF6 →	+0.665	+1.256	.005	<.001	3	3
LUNG_SCLC	CYP19A1 →	-0.789	-1.091	.001	.004	3	3
LUNG_SCLC	HES6 →	-3.181	-1.313	.005	.001	3	3
LUNG_SCLC	MCIDAS →	+1.346	+1.223	.004	.006	3	3
LUNG_SCLC	ETV5 →	+2.715	+1.120	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A23 by Chemorepulsion of axon activity — CNS

Explore this box plot interactively →