Cytoskeleton-dependent cytokinesis

Across TCGA cell cohorts, RNA activity of the Cytoskeleton-dependent cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIN52, FUT11, and SLC10A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIN52 grouped by Cytoskeleton-dependent cytokinesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LIN52 →	-0.683	-0.205	<.001	.002	3	5
URINARY_TRACT	FUT11 →	-1.188	-0.276	<.001	.003	2	5
STOMACH	SLC10A3 →	+0.576	+0.207	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	SNX25 →	+0.680	+0.164	.009	.004	3	4
UPPER_AERODIGESTIVE_TRACT	MYO10 →	+1.078	+0.192	<.001	<.001	3	4
OESOPHAGUS	UBE2O →	-0.680	-0.213	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIN52 by Cytoskeleton-dependent cytokinesis activity — STOMACH

Explore this box plot interactively →