Cytoskeleton-dependent cytokinesis

Across TCGA cell cohorts, RNA activity of the Cytoskeleton-dependent cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2D, PPP2CA, and TXNDC15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoskeleton-dependent cytokinesis activity versus CDKN2D in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDKN2D →	+1.233	+0.144	.001	.008	3	6
URINARY_TRACT	PPP2CA →	+0.778	+0.332	.001	.006	3	5
URINARY_TRACT	TXNDC15 →	+1.040	+0.312	.006	.003	3	5
BLOOD_Lymphoma	NTAN1 →	+0.576	+0.173	.009	<.001	3	5
LIVER	PRADC1 →	+0.698	+0.112	.001	.001	3	5
LIVER	RGS14 →	-1.449	-0.106	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061640 vs CDKN2D — BLOOD_Leukemia

Explore this scatter interactively →