Regulation of protein complex stability

Across TCGA patient cohorts, RNA activity of the Regulation of protein complex stability pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3GLB1, MSI2, and RHOT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein complex stability activity versus SH3GLB1 in LSCC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH3GLB1 →	-0.193	-0.075	.002	<.001	3	5
BRCA	MSI2 →	+0.395	+0.048	.003	<.001	3	5
CCRCC	RHOT1 →	+0.225	+0.039	<.001	<.001	3	5
PDAC	AATF →	+0.335	+0.035	<.001	.001	3	4
LUAD	ATXN2L_S306 →	+0.721	+0.053	<.001	.001	3	4
LSCC	TBCD →	+0.382	+0.077	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061635 vs SH3GLB1 — LSCC

Explore this scatter interactively →