Regulation of protein complex stability

Across TCGA cell cohorts, RNA activity of the Regulation of protein complex stability pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF2, DTNA, and GALC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ILF2 grouped by Regulation of protein complex stability-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ILF2 →	+0.684	+1.918	.005	<.001	3	5
OESOPHAGUS	DTNA →	+1.411	+0.844	.007	.001	3	4
SOFT_TISSUE	GALC →	-2.236	-1.181	.001	.008	3	4
PANCREAS	PTP4A3 →	+1.435	+1.031	.003	.002	3	4
LARGE_INTESTINE	LYZ →	+3.428	+0.525	.001	.005	2	4
OESOPHAGUS	MAP7D1 →	-0.675	-0.771	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ILF2 by Regulation of protein complex stability activity — SOFT_TISSUE

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