Regulation of protein complex stability

Across TCGA cell cohorts, RNA activity of the Regulation of protein complex stability pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAPBP, TNFRSF14, and ELMOD2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein complex stability activity versus TAPBP in BONE (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TAPBP →	+1.283	+0.137	.001	<.001	3	11
BONE	TNFRSF14 →	+1.948	+0.124	<.001	<.001	3	10
SKIN	ELMOD2 →	+0.730	+0.111	<.001	<.001	3	10
URINARY_TRACT	PCM1 →	+0.799	+0.107	.001	.001	3	9
BONE	TNFRSF9 →	+1.040	+0.114	.006	.002	3	9
SOFT_TISSUE	DDX60 →	+1.617	+0.084	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061635 vs TAPBP — BONE

Explore this scatter interactively →