Regulation of protein complex stability

Across TCGA cell cohorts, RNA activity of the Regulation of protein complex stability pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL1, APOL6, and PSMB9, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein complex stability activity versus APOL1 in LIVER (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	APOL1 →	+5.101	+0.221	<.001	.005	3	11
STOMACH	APOL6 →	+2.846	+0.398	<.001	<.001	3	11
BREAST	PSMB9 →	+2.708	+0.350	<.001	<.001	3	11
PANCREAS	DDX60 →	+2.688	+0.366	.002	<.001	3	10
PANCREAS	TAPBP →	+1.051	+0.257	<.001	<.001	3	10
BREAST	HLA-C →	+2.111	+0.379	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061635 vs APOL1 — LIVER

Explore this scatter interactively →