Glycolytic process through glucose-6-phosphate

Across TCGA patient cohorts, RNA activity of the Glycolytic process through glucose-6-phosphate pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIDAP2, RNU6-1327P, and PGK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolytic process through glucose-6-phosphate activity versus AIDAP2 in UCEC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AIDAP2 →	-0.691	-0.128	.001	.003	3	5
GBM	RNU6-1327P →	-0.729	-0.177	<.001	.004	3	5
PDAC	PGK1 →	+0.795	+0.223	<.001	<.001	3	5
HNSC	ENO2 →	+0.987	+0.127	.003	.009	2	5
HNSC	EGLN3 →	+1.235	+0.158	<.001	<.001	3	4
HNSC	TK1 →	+0.827	+0.161	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061620 vs AIDAP2 — UCEC

Explore this scatter interactively →