Glycolytic process through glucose-6-phosphate

Across TCGA patient cohorts, RNA activity of the Glycolytic process through glucose-6-phosphate pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PFKP_S386, PKM_S127, and ENO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolytic process through glucose-6-phosphate activity versus PFKP_S386 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PFKP_S386 →	+0.851	+0.208	<.001	<.001	3	5
CCRCC	PKM_S127 →	+0.614	+0.176	<.001	<.001	3	5
CCRCC	ENO1 →	+0.475	+0.177	<.001	<.001	3	4
GBM	ENO1_S141 →	+0.735	+0.213	<.001	<.001	3	4
CCRCC	ENO1_S254 →	+1.249	+0.276	<.001	<.001	3	4
LUAD	INF2_T1179 →	+1.105	+0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061620 vs PFKP_S386 — PDAC

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