Glycolytic process through fructose-6-phosphate

Across TCGA patient cohorts, RNA activity of the Glycolytic process through fructose-6-phosphate pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC16A3, HK2, and ITGA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolytic process through fructose-6-phosphate activity versus SLC16A3 in PDAC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC16A3 →	+0.579	+0.041	.001	.002	3	7
CCRCC	HK2 →	+0.601	+0.043	.001	.003	3	7
PDAC	ITGA5 →	+0.646	+0.055	<.001	<.001	3	7
PDAC	SCLY →	-0.313	-0.042	.001	<.001	3	7
BRCA	DDAH1 →	-0.750	-0.058	<.001	<.001	3	7
BRCA	P4HA1 →	+0.650	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061615 vs SLC16A3 — PDAC

Explore this scatter interactively →