Glycolytic process through fructose-6-phosphate

Across TCGA patient cohorts, RNA activity of the Glycolytic process through fructose-6-phosphate pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGLN3, CBFA2T3, and HILPDA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolytic process through fructose-6-phosphate activity versus EGLN3 in PDAC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	EGLN3 →	+1.112	+0.176	.003	<.001	3	5
BRCA	CBFA2T3 →	-0.921	-0.125	<.001	.004	3	4
CCRCC	HILPDA →	+0.971	+0.147	.002	<.001	3	4
LSCC	CNTD1 →	-0.271	-0.119	<.001	<.001	3	4
LUAD	HIF1A-AS3 →	+0.825	+0.185	<.001	<.001	3	4
CCRCC	PRKAR2B →	-0.482	-0.120	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061615 vs EGLN3 — PDAC

Explore this scatter interactively →