Glycolytic process through fructose-6-phosphate

Across TCGA cell cohorts, RNA activity of the Glycolytic process through fructose-6-phosphate pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPI, TSPO, and MED11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolytic process through fructose-6-phosphate activity versus GPI in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPI →	+0.883	+0.404	.002	<.001	2	7
LUNG_NSCLC_LUAD	TSPO →	+1.092	+0.204	.007	.003	3	6
BLOOD_Myeloma	MED11 →	+0.882	+0.165	.008	.003	3	5
UPPER_AERODIGESTIVE_TRACT	HADH →	+0.970	+0.415	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MFF →	+1.117	+0.195	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ATP6V0E2 →	+1.688	+0.413	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061615 vs GPI — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →