Calcium activated phospholipid scrambling

Across TCGA patient cohorts, RNA activity of the Calcium activated phospholipid scrambling pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC1, HDAC1_S410, and PDS5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium activated phospholipid scrambling activity versus HDAC1 in CCRCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HDAC1 →	+0.143	+0.060	.001	<.001	3	4
OV	HDAC1_S410 →	+0.586	+0.141	<.001	.001	3	4
COAD	PDS5B →	+0.251	+0.106	<.001	<.001	3	4
COAD	VDAC1 →	+0.364	+0.087	<.001	<.001	3	4
COAD	AK2 →	+0.257	+0.089	.001	.003	3	4
COAD	GLYR1 →	+0.218	+0.108	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061588 vs HDAC1 — CCRCC

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