Calcium activated phospholipid scrambling

Across TCGA patient cohorts, RNA activity of the Calcium activated phospholipid scrambling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL9P21, ACTG1P14, and EEF1GP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium activated phospholipid scrambling activity versus RPL9P21 in GBM (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL9P21 →	+0.255	+0.629	.002	.002	3	4
GBM	ACTG1P14 →	+0.353	+0.559	.008	.005	3	3
BRCA	EEF1GP1 →	+1.802	+0.177	.007	.004	3	3
BRCA	EEF1A1P1 →	+2.205	+0.287	<.001	.009	2	4
BRCA	HMGN2P19 →	+0.986	+0.223	.004	<.001	3	3
GBM	UBE2L5 →	+0.179	+0.811	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061588 vs RPL9P21 — GBM

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