Calcium ion transmembrane transport via high voltage-gated calcium channel

Across TCGA patient cohorts, RNA activity of the Calcium ion transmembrane transport via high voltage-gated calcium channel pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1438, STXBP1, and MAP1B_S2271, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion transmembrane transport via high voltage-gated calcium channel activity versus MAP1B_S1438 in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1438 →	+0.712	+0.041	<.001	<.001	3	7
UCEC	STXBP1 →	+0.443	+0.053	<.001	<.001	3	6
LUAD	MAP1B_S2271 →	+0.597	+0.039	.009	.006	2	7
UCEC	SEPTIN11 →	+0.275	+0.042	<.001	.003	3	5
UCEC	SNX9 →	+0.443	+0.069	<.001	<.001	3	5
UCEC	AKAP12_S1395 →	+0.709	+0.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061577 vs MAP1B_S1438 — LSCC

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