Calcium ion transmembrane transport via high voltage-gated calcium channel

Across TCGA patient cohorts, RNA activity of the Calcium ion transmembrane transport via high voltage-gated calcium channel pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHISAL1, PODN, and AJAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion transmembrane transport via high voltage-gated calcium channel activity versus SHISAL1 in GBM (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SHISAL1 →	+1.115	+0.809	<.001	.002	3	5
GBM	PODN →	+0.910	+0.801	<.001	.002	3	4
GBM	AJAP1 →	+0.902	+0.926	.004	.002	3	4
UCEC	GFRA2 →	+0.364	+0.654	.007	.002	2	5
LUAD	CPEB3 →	+0.256	+0.599	<.001	<.001	3	3
BRCA	SLC1A7 →	+0.350	+0.541	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061577 vs SHISAL1 — GBM

Explore this scatter interactively →