Calcium ion transmembrane transport via high voltage-gated calcium channel

Across TCGA cell cohorts, RNA activity of the Calcium ion transmembrane transport via high voltage-gated calcium channel pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R14B, IL4R, and RPS17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R14B grouped by Calcium ion transmembrane transport via high voltage-gated calcium channel-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPP1R14B →	+0.946	+0.905	.001	.002	3	4
BLOOD_Lymphoma	IL4R →	-4.970	-2.357	.003	<.001	3	4
LARGE_INTESTINE	RPS17 →	+0.518	+0.893	.005	.005	3	4
URINARY_TRACT	LYSMD2 →	+1.713	+0.357	.002	<.001	2	4
URINARY_TRACT	CEP44 →	+1.033	+0.417	.008	.005	3	3
BLOOD_Myeloma	TJP3 →	-0.986	-1.464	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R14B by Calcium ion transmembrane transport via high voltage-gated calcium channel activity — BREAST

Explore this box plot interactively →