Sympathetic ganglion development

Across TCGA patient cohorts, RNA activity of the Sympathetic ganglion development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, SULF2, and FKBP10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic ganglion development activity versus FN1 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FN1 →	+0.933	+0.078	.005	.001	3	6
BRCA	SULF2 →	+0.517	+0.050	.008	.004	3	6
LSCC	FKBP10 →	+0.528	+0.087	<.001	<.001	3	6
LSCC	FKBP9 →	+0.351	+0.084	<.001	<.001	3	6
OV	NRP2 →	+0.553	+0.063	<.001	.009	2	7
LSCC	THBS1 →	+0.765	+0.061	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061549 vs FN1 — OV

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