Sympathetic ganglion development

Across TCGA patient cohorts, RNA activity of the Sympathetic ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VENTX, GEM, and C8orf88, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic ganglion development activity versus VENTX in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VENTX →	+0.497	+0.157	.002	.003	3	4
OV	GEM →	+1.187	+0.224	.004	<.001	3	4
COAD	C8orf88 →	+0.595	+0.123	.003	.007	2	5
LSCC	CDH11 →	+0.538	+0.101	.001	.003	3	4
LSCC	NAALADL1 →	+0.307	+0.100	<.001	.003	3	4
LSCC	ITGA1 →	+0.361	+0.098	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061549 vs VENTX — LSCC

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