Hindgut development

Across TCGA patient cohorts, RNA activity of the Hindgut development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSGEPL1, GLI3, and SYDE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindgut development activity versus OSGEPL1 in BRCA (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OSGEPL1 →	+0.391	+0.258	.001	<.001	3	4
BRCA	GLI3 →	+0.935	+0.277	<.001	<.001	3	4
PDAC	SYDE1 →	+0.297	+0.177	<.001	<.001	3	4
PDAC	RIMKLB →	+0.530	+0.166	.004	.007	3	4
UCEC	KIF7 →	+0.509	+0.309	.007	.009	3	4
PDAC	NID2 →	+0.503	+0.211	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061525 vs OSGEPL1 — BRCA

Explore this scatter interactively →