Cilium disassembly

Across TCGA patient cohorts, RNA activity of the Cilium disassembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD18, MAP4, and SNHG10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium disassembly activity versus BTBD18 in HNSC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BTBD18 →	-0.523	-0.119	.005	.002	3	4
HNSC	MAP4 →	+0.529	+0.164	.003	.001	3	4
OV	SNHG10 →	-0.517	-0.611	<.001	.001	3	4
LSCC	RPS6KA5 →	-0.482	-0.368	.005	.008	3	4
BRCA	SPRYD4 →	-0.242	-0.123	.002	.006	3	4
BRCA	RPL31P52 →	-0.349	-0.134	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061523 vs BTBD18 — HNSC

Explore this scatter interactively →