Cilium disassembly

Across TCGA cell cohorts, RNA activity of the Cilium disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4, DPH5, and RAB5A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium disassembly activity versus MAP4 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP4 →	+1.233	+1.072	.002	.006	2	8
BREAST	DPH5 →	+1.063	+1.205	<.001	.001	3	5
BREAST	RAB5A →	+0.758	+1.405	.006	.001	2	6
PANCREAS	CCDC71 →	+1.402	+1.882	.001	<.001	2	6
OVARY	OSBPL2 →	-0.894	-0.911	.001	.005	3	5
OVARY	EPS8L1 →	-4.528	-1.498	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061523 vs MAP4 — BREAST

Explore this scatter interactively →