Microglial cell proliferation

Across TCGA patient cohorts, RNA activity of the Microglial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF1, VSIR, and ABI3, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglial cell proliferation activity versus CSF1 in BLCA (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CSF1 →	+1.554	+0.108	<.001	<.001	3	32
SCLC	VSIR →	+1.677	+0.784	<.001	<.001	3	31
SCLC	ABI3 →	+2.429	+0.732	<.001	<.001	3	31
CHOL	SLC15A3 →	+1.869	+0.145	<.001	<.001	3	31
CHOL	SELPLG →	+2.431	+0.187	<.001	<.001	3	31
SCLC	CSF3R →	+2.010	+0.656	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061518 vs CSF1 — BLCA

Explore this scatter interactively →