Microglial cell proliferation

Across TCGA patient cohorts, RNA activity of the Microglial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL33, STAB1, and HLA-DRA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglial cell proliferation activity versus IL33 in HNSC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IL33 →	+0.577	+0.103	<.001	<.001	3	9
HNSC	STAB1 →	+0.389	+0.145	<.001	<.001	3	8
HNSC	HLA-DRA →	+0.696	+0.122	<.001	<.001	3	8
BRCA	TMOD1 →	+0.701	+0.076	<.001	<.001	3	8
LUAD	SNX18 →	+0.279	+0.097	<.001	<.001	3	8
CCRCC	TNXB →	+0.912	+0.098	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061518 vs IL33 — HNSC

Explore this scatter interactively →