Macrophage proliferation

Across TCGA patient cohorts, RNA activity of the Macrophage proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNBP1, TMOD1, and ANK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage proliferation activity versus FNBP1 in HNSC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FNBP1 →	+0.372	+0.096	<.001	<.001	3	9
BRCA	TMOD1 →	+0.734	+0.089	<.001	<.001	3	9
HNSC	ANK2 →	+0.410	+0.078	.006	.005	3	8
UCEC	SOD3 →	+0.710	+0.094	<.001	<.001	3	8
UCEC	STAB1 →	+0.386	+0.146	<.001	<.001	3	8
CCRCC	SORBS1 →	+0.508	+0.074	.004	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061517 vs FNBP1 — HNSC

Explore this scatter interactively →