Myeloid cell development

Across TCGA patient cohorts, RNA activity of the Myeloid cell development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, SNAI2, and FBLN5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell development activity versus MMP19 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP19 →	+1.617	+0.449	<.001	<.001	3	6
GBM	SNAI2 →	+1.051	+0.222	<.001	<.001	3	6
CCRCC	FBLN5 →	+1.021	+0.284	.003	.002	3	5
BRCA	SERPINH1 →	+0.791	+0.481	.001	.002	3	5
CCRCC	VEGFC →	+0.778	+0.306	<.001	<.001	3	5
GBM	NNMT →	+2.273	+0.366	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061515 vs MMP19 — GBM

Explore this scatter interactively →