Myeloid cell development

Across TCGA cell cohorts, RNA activity of the Myeloid cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2B3, PBXIP1, and FOSL1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell development activity versus SH2B3 in LUNG_NSCLC_LUSC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SH2B3 →	+1.908	+0.101	<.001	<.001	3	9
OVARY	PBXIP1 →	-0.998	-0.084	<.001	<.001	3	8
OVARY	FOSL1 →	+3.484	+0.089	<.001	<.001	3	8
SOFT_TISSUE	CCDC85B →	+1.863	+0.081	.001	<.001	3	8
LUNG_NSCLC_LUAD	ZFP14 →	-0.381	-0.043	.009	.006	3	7
SKIN	TSPAN10 →	-1.341	-0.043	.005	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061515 vs SH2B3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →