Centriole elongation

Across TCGA patient cohorts, RNA activity of the Centriole elongation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CIAO2B, PKP3, and SDC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole elongation activity versus CIAO2B in GBM (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CIAO2B →	-0.265	-0.050	.001	.001	3	5
HNSC	PKP3 →	-0.921	-0.065	<.001	<.001	3	5
GBM	SDC4 →	-0.629	-0.049	<.001	.001	3	4
UCEC	AKAP5_S81 →	+0.460	+0.050	.003	.003	3	4
COAD	UNC119 →	+0.683	+0.074	.002	<.001	3	4
COAD	MORF4L1 →	+0.241	+0.026	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061511 vs CIAO2B — GBM

Explore this scatter interactively →