Centriole elongation

Across TCGA patient cohorts, RNA activity of the Centriole elongation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGP, ZNF410, and DIAPH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole elongation activity versus PIGP in UCEC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIGP →	-0.282	-0.295	.004	.002	3	3
BRCA	ZNF410 →	+0.194	+0.459	.006	.002	3	3
GBM	DIAPH1 →	+0.292	+0.499	.003	.009	2	4
BRCA	KLF16 →	+0.362	+0.310	.008	.005	3	3
BRCA	LMX1B →	+1.150	+0.497	<.001	.001	3	3
BRCA	PTGR2 →	+0.419	+0.552	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061511 vs PIGP — UCEC

Explore this scatter interactively →