Hematopoietic stem cell homeostasis

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, TNS2, and VCL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell homeostasis activity versus RPS2 in COAD (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS2 →	-0.164	-0.022	<.001	<.001	3	9
UCEC	TNS2 →	+0.408	+0.067	<.001	<.001	3	9
UCEC	VCL →	+0.717	+0.083	<.001	<.001	3	9
UCEC	CNRIP1 →	+0.800	+0.062	<.001	<.001	3	9
BRCA	FRZB →	+0.884	+0.050	<.001	<.001	3	9
UCEC	GUCY1B1 →	+0.489	+0.058	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061484 vs RPS2 — COAD

Explore this scatter interactively →