Hematopoietic stem cell homeostasis

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP12, CBX2, and ANKRD44-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell homeostasis activity versus THAP12 in OV (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THAP12 →	+0.528	+0.708	.005	.003	3	3
COAD	CBX2 →	+0.643	+0.394	.001	.001	3	3
COAD	ANKRD44-AS1 →	-0.247	-0.358	.002	.004	3	3
HNSC	MAPK13 →	+0.472	+0.405	.005	.007	3	3
HNSC	SIRPB2 →	-0.384	-0.434	.007	.003	3	3
HNSC	GRHL2 →	+0.793	+0.721	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061484 vs THAP12 — OV

Explore this scatter interactively →