Hematopoietic stem cell homeostasis

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLE1, FOXA3, and ADAR, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLE1 grouped by Hematopoietic stem cell homeostasis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NLE1 →	-0.300	-0.636	<.001	.006	3	9
SOFT_TISSUE	FOXA3 →	-0.428	-0.972	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	ADAR →	-0.564	-0.456	.008	.002	2	6
SOFT_TISSUE	ALOXE3 →	-0.156	-0.711	.003	.004	3	5
LUNG_NSCLC_LUSC	GTF3C3 →	-0.284	-0.527	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	GPR52 →	+0.293	+0.352	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLE1 by Hematopoietic stem cell homeostasis activity — SKIN

Explore this box plot interactively →